Our mission is to ensure the generation of accurate and precise findings.
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From concept to commercial, we transform your ideas into solutions for better health. We provide you global resources and proven capabilities at every stage of the biopharma lifecycle, in small and large molecules. Our ability to offer end-to-end solutions or support standalone programs is underpinned by an innovation mindset, enabling technologies, and a partnership approach to every engagement.
Biotransformation is our core area of interest. Application of biotransformation of drugs by mammalian systems, microorganisms, and recombinant enzymes, covering active and reactive metabolites, the impact of the gut microbiome on metabolism, and how insights gained from biotransformation studies can influence drug design. Our core focus is to study initial interaction with enzymes. Inhibition or induction might affect the absorption of medicines that are substrates to these enzymes. Drugs, herbal supplements, dietary ingredients, and some pharmaceutical excipients have been demonstrated to influence the activity of these enzymes.
Key Focus areas :
Currently, we are in the very early stage of discovery of novel drug candidates. We have particular skills in the pharmacology of G protein-coupled receptors and the role of allostery and based signaling in receptor pharmacology. We align our interest with structure-based drug design and the use of fragment-based screening in drug discovery. Identification of optimal pharmaceutical properties for drug molecules during hit-to-lead and lead optimization through to candidate selection is being done with partners to target our key Therapeutic Program Areas.